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2-Chloronicotinic acid → 2-[4-(2-Hydroxypropyl)piperazin-1-yl]nicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloronicotinic acid | HCID 76258 | — |
| 反応物 | alpha-Methyl-1-piperazineethanol | HCID 258198 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-[4-(2-Hydroxypropyl)piperazin-1-yl]nicotinic acid | HCID 20032000 | — |
反応手順
Grams 3 of 1-(2-hydroxypropyl)piperazine and 1.6 g of 2-chloronicotinic acid in 50 ml dioxane were refluxed for 2 days. The react ion mixture was cooled, then allowed to rest for 2 days, the solvent was removed and the residue was crystallized from absolute ethanol to give 1.2 g of 2-[4-(2-hydroxypropyl)piperazin-1-yl]nicotinic acid, melting at 222°-223° C. (with decomposition).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04849422 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-8296e3fc1a37408dbfc29642a5e33d9f |
| 出典メモ | uspto-grants-1989_07 |