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2-Chloronicotinic acid → 2-{4-[2-(2-Hydroxy ethoxy)ethyl]piperazin-1-yl}nicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloronicotinic acid | HCID 76258 | — |
| 反応物 | 1-[2-(2-Hydroxyethoxy)ethyl]piperazine | HCID 139436 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-{4-[2-(2-Hydroxy ethoxy)ethyl]piperazin-1-yl}nicotinic acid | HCID 20032014 | — |
反応手順
Grams 5.9 of 1-(2-hydroxyethoxyethyl)piperazine and 2.7 g of 2-chloronicotinic acid in 50 ml dioxane were refluxed for 3 days. The reaction mixture was then cooled and allowed to rest for 2 days, afterwards the solvent was removed and the residue crystallized from absolute ethanol, gave 1.1 g of 2-{4-[2-(2-hydroxy ethoxy)ethyl]piperazin-1-yl}nicotinic acid melting at 172°-174° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04849422 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-3a6e8d7cf8b340888fd9d3b28157e5fc |
| 出典メモ | uspto-grants-1989_07 |