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2-Amino-2-methyl-1-propanol → 2-[[(1-Oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl]amino]-2-methyl-1-propanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| 反応物 | Ethyl 1,3-dihydro-1-oxoisobenzofuran-5-carboxylate | HCID 90088 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-[[(1-Oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl]amino]-2-methyl-1-propanol | HCID 11196005 | — |
反応手順
Method B): 5-Ethoxycarbonylphthalid (82 g, 0.4 mole) is added to a solution of 2-amino-2-methylpropan-1-ol (44.6 g. 0.5 mole) in toluene (100 ml). The mixture is heated to reflux temperature for 24 hours. Upon cooling the title compound is filtered off and recrystallised from hot toluene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849749B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-b1c7e6f305a2432c90684e7fd8d07359 |
| 出典メモ | uspto-grants-2005_02 |