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N-(hydroxymethyl)phthalimide → Phthalimidomethyl acetoacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(hydroxymethyl)phthalimide | HCID 8354 | — |
| 反応物 | 2,2,6-Trimethyl-4H-1,3-dioxin-4-one | HCID 79368 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Phthalimidomethyl acetoacetate | HCID 13636318 | 97.8% |
反応手順
A solution of 10.0 g (0.056 mol) of N-(hydroxymethyl)phthalimide and 8.02 g (0.056 mol) of 2,2,6-trimethyl-1,3-dioxen-4-one in 100 ml of toluene was refluxed for 24 hours under nitrogen. Recrystallization in ethyl acetate gives 14.3 g (97%) of an off-white solid: mp 106°-109° C.; NMR (CDCl3) 7.6 (4H,m), 5.6 (2H,s), 3.4 (2H,s), 2.18 (3H,s);
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04849436 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-a4b5f533bb0d42aab6cb22fa1ea960d1 |
| 出典メモ | uspto-grants-1989_07 |