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4,6-Dichloro-5-(4-methylphenyl)pyrimidine → 5-(4-Methylphenyl)-4,6-dichloro-2-phenylpyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dichloro-5-(4-methylphenyl)pyrimidine | HCID 21979554 | — |
| 反応物 | HCID 178418453 | HCID 178418453 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 5-(4-Methylphenyl)-4,6-dichloro-2-phenylpyrimidine | HCID 19689470 | — |
反応手順
A solution of 5-(4-methylphenyl)-4,6-dichloropyrimidine in ether is cooled at -30° C., and thereto is added dropwise a 1.8M phenyl lithium/cyclohexane solution. The reaction mixture is treated in the same manner as in Reference Example 20-(1) to give 5-(4-methylphenyl)-4,6-dichloro-2-phenylpyrimidine as crystalline powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728706 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-92159ddf5fca43a09bd60ede97b3d342 |
| 出典メモ | uspto-grants-1998_03 |