Sodium Cyanide → Cypermethrin

HRID 231908

反応式

HRID 231908 の反応式
[Cl:1][C:2]([Cl:12])=[CH:3][CH:4]1[CH:6]([C:7]([OH:9])=[O:8])[C:5]1([CH3:11])[CH3:10].[O:13]([C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH:23]=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C-:28]#[N:29].[Na+].CS(Cl)(=O)=O>C1(C)C=CC=CC=1.CN1CCCC1=O>[Cl:1][C:2]([Cl:12])=[CH:3][CH:4]1[CH:6]([C:7]([O:9][CH:23]([C:28]#[N:29])[C:22]2[CH:25]=[CH:26][CH:27]=[C:20]([O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:21]=2)=[O:8])[C:5]1([CH3:10])[CH3:11]

参加物

7

反応物 4

HCID 8929Sodium CyanideHCID 31297Methanesulfonyl chlorideHCID 382843-PhenoxybenzaldehydeHCID 91658Permethric acid

生成物 1

HCID 2912Cypermethrin

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

Following the procedure of Example 1, to a mixture of 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (50 mmol), 3-phenoxybenzaldehyde (9.90 g, 50 mmol), N-methylpyrrolidinone (10 g) and "mixed" picolines (8.5 g) in toluene is added sodium cyanide (2.57 g, 52.5 mmol), followed ca. 3 hours later by slow addition of methanesulfonyl chloride (6.87 g, 60 mmol). The reaction mixture is worked up and the solvent is removed to give α-cyano-3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate.

後処理

  1. customthe solvent is removed

出典と根拠

ORDレコード
ord-ff3f95f16fe2491a9ec318cc889b16e4
出典データセット
uspto-grants-1989_07
特許番号
US04849536

関連ノート

読み込み中…