3-Amino-4-methoxycyclobut-3-ene-1,2-dione → 3-Amino-4-[4-(4-piperidinomethylpyrazol-1-yloxy)-butylamino]-cyclobutene-1,2-dione
反応式
[N:1]1([CH2:7][C:8]2[CH:9]=[N:10][N:11]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][NH2:18])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:19][C:20]1[C:21](=[O:27])[C:22](=[O:26])[C:23]=1OC>CO>[NH2:19][C:20]1[C:21](=[O:27])[C:22](=[O:26])[C:23]=1[NH:18][CH2:17][CH2:16][CH2:15][CH2:14][O:13][N:11]1[CH:12]=[C:8]([CH2:7][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:9]=[N:10]1参加物
4
反応条件
- 温度
- 20 °C
実験手順
2.5 g of 4-(4-piperidinomethylpyrazol-1-yloxy)butylamine and 1.2 g of 3-amino-4-methoxycyclobutene-1,2-dione are introduced into 80 ml of methanol, and the mixture is stirred for 12 hours at 20° C. The solid formed is then filtered off under suction.