Ammonia → HCID 20030990、化合物
反応式
C[O:2][C:3]([C:5]1[N:6]=[CH:7][N:8]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[CH:9]=1)=O.[NH3:18]>CO>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH2:10][N:8]1[CH:9]=[C:5]([C:3]([NH2:18])=[O:2])[N:6]=[CH:7]1参加物
4
実験手順
4.0 g of 1-(o-fluorobenzyl)-imidazole-4-carboxylic acid methyl ester are dissolved in 80 ml of methanol and transferred to an autoclave. 20.0 g of ammonia are introduced under pressure and the whole is heated at 100° for 19 hours. When the excess ammonia has been blown off, the resulting product is filtered off and recrystallised from ethanol. 1-(o-fluorobenzyl)-imidazole-4-carboxamide having a melting point of 204°-205° is obtained.
後処理
- temperaturethe whole is heated at 100° for 19 hours
- filtrationthe resulting product is filtered off
- customrecrystallised from ethanol
出典と根拠
- ORDレコード
- ord-5d36cb385912499d8f34a5e3dc690089
- 出典データセット
- uspto-grants-1989_07
- 特許番号
- US04851424
反応ノート
読み込み中…