Ethanethiol → 3-Ethylthio-2-oxoglutaric acid
反応式
Br[CH:2]([CH2:8][C:9]([OH:11])=[O:10])[C:3](=[O:7])[C:4]([OH:6])=[O:5].[CH2:12]([SH:14])[CH3:13].C(N(CC)CC)C>ClCCl>[CH2:12]([S:14][CH:2]([CH2:8][C:9]([OH:11])=[O:10])[C:3](=[O:7])[C:4]([OH:6])=[O:5])[CH3:13]参加物
5
実験手順
In 20 ml of dichloromethane was suspended 1.00 g of 3-bromo-2-oxoglutaric acid. To the suspension was added 0.33 ml of ethane thiol under ice-cooling and stirring, to which was added 1.83 ml of triethylamine. The reaction solution was stirred at room temperature for 3 hours, then the solvent was evaporated off. The residue was shaken with a mixture of ethyl acetate and 1N-HCl. The ethyl acetate layer was taken, washed with water and dried (Na2SO4). The solvent was evaporated off to give 0.82 g of 3-ethylthio-2-oxoglutaric acid as pale yellow oil.
後処理
- temperaturecooling
- stirringThe reaction solution was stirred at room temperature for 3 hours
- customthe solvent was evaporated off
- stirringThe residue was shaken with a mixture of ethyl acetate and 1N-HCl
- washwashed with water
- dry with materialdried (Na2SO4)
- customThe solvent was evaporated off
出典と根拠
- ORDレコード
- ord-def02507baea4e32b7f811a31270ba82
- 出典データセット
- uspto-grants-1989_07
- 特許番号
- US04851422
反応ノート
読み込み中…