Dicyclohexylcarbodiimide → HCID 67901861、化合物

HRID 232230ノート

反応式

HRID 232230 の反応式
[CH3:1][O:2][CH:3]([C:20]([O-:22])=[O:21])[CH2:4][C:5](=O)[C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1)=[O:7].[CH2:23]([O:30][C:31]([NH:33][C@H:34]1[CH2:38][O:37][NH:36][C:35]1=[O:39])=[O:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C1CCC(N=C=NC2CCCCC2)CC1>ClCCl>[CH2:23]([O:30][C:31]([NH:33][C@H:34]1[CH2:38][O:37][N:36]([C:5]2([C:6]([O:8][CH2:9][C:10]3[CH:11]=[CH:12][C:13]([N+:16]([O-:18])=[O:17])=[CH:14][CH:15]=3)=[O:7])[CH2:4][CH:3]([O:2][CH3:1])[C:20](=[O:21])[O:22]2)[C:35]1=[O:39])=[O:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

5

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 14181640HCID 14181640、化合物HCID 67902313HCID 67902313、化合物

生成物 1

HCID 67901861HCID 67901861、化合物収率 47.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In 10 ml of dichloromethane was dissolved 896 mg of Compound (93). To the solution were added 680 mg of (4S)-4-benzyloxycarbonylamino-3-isoxazolidinone and 593 mg of DCC, and the mixture was stirred at room temperature for one hour. Then, precipitating crystals were filtered off, and the solvent was evaporated off. The residue was subjected to a silica gel column chromatography, followed by elution with hexane--ethyl acetate (3:2) to give 723 mg of the subject Compound (94) as an oily product.

後処理

  1. customThen, precipitating crystals
  2. filtrationwere filtered off
  3. customthe solvent was evaporated off
  4. washfollowed by elution with hexane--ethyl acetate (3:2)

出典と根拠

ORDレコード
ord-9f9d8d815f4145bbbbf55d6f45a20a66
出典データセット
uspto-grants-1989_07
特許番号
US04851422

反応ノート

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