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Hydrochloric Acid → 3-Oxocycloheptane-1-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Cyclohepten-1-one | HCID 70723 | — |
| 反応物 | Diethyl aluminum cyanide | HCID 16686413 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-Oxocycloheptane-1-carbonitrile | HCID 15702746 | — |
反応手順
To 100 mL of toluene add 2-cyclohepten-1-one (11.0 g, 0.1 mol) and 200 mL (1M solution in toluene, 0.2 mol) of diethylaluminum cyanide. Monitor the reaction by thin-layer chromatography. Upon completion add 1M aqueous HCl until gas evolution ceases. Extract twice with 100 mL of ether. Dry the organic phase with Na2SO4. Filter off the drying agent and evaporate the solvent in vacuo to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04851526 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-e95315393a654245bf2d5423cbf03910 |
| 出典メモ | uspto-grants-1989_07 |