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Hydrochloric Acid → 1,2-Diethyl-4-piperidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Boron trifluoride etherate | HCID 8000 | — |
| 反応物 | 1-Propanamine, N-ethyl- | HCID 88398 | — |
| 反応物 | 2-(Trimethylsiloxy)-1,3-butadiene | HCID 554657 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1,2-Diethyl-4-piperidinone | HCID 20031315 | — |
反応手順
To 100 mL of methylene chloride cooled to 0° C. is added 2-(trimethylsilyloxy)-1,3-butadiene (14.2 g, 0.1 mol), 8.5 g (0.1 mol) of N-ethyl-propanamine, and 14.2 g (0.1 mol) of borontrifluoride etherate. Monitor the reaction by thinlayer chromatography. Upon completion add 1N HCl until gas evolution ceases. Separate the aqueous layer and make it alkaline with 1N NaOH. Extract twice with 100 mL ether and dry over Na2SO4. Filter the drying agent and evaporated the solvent in vacuo to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04851526 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-dc7eb3e1a8054954978500e3c6bd556b |
| 出典メモ | uspto-grants-1989_07 |