Hydrochloric Acid → HCID 20031401、化合物

HRID 232288ノート

反応式

HRID 232288 の反応式
[C-:1]#[N:2].[Na+].CS(O[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[N:15]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=O)=O.Cl>CCOCC>[C:17]1([CH2:16][N:15]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]2[C:1]#[N:2])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8929Sodium CyanideHCID 54076726HCID 54076726、化合物

生成物 1

HCID 20031401HCID 20031401、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To 100 mL of ether is added 10 g (0.2 mol) of sodium cyanide and 37.3 g (0.1 mol) of 2-[bis(phenylmethyl)amino]-cyclohexanol methanesulfonate. Reflux the reaction and monitor by thin-layer chromatography. Upon completion add 1N HCl until gas evolution ceases. Remove the solvent in vacuo and add saturated aqueous sodium bicarbonate and 100 mL methylene chloride. Dry the organic phase over Na2SO4. Filter off the drying agent and evaporate the solvent in vacuo to obtain the title compound.

後処理

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. customRemove the solvent in vacuo
  4. additionadd saturated aqueous sodium bicarbonate and 100 mL methylene chloride
  5. dry with materialDry the organic phase over Na2SO4
  6. filtrationFilter off the drying agent
  7. customevaporate the solvent in vacuo

出典と根拠

ORDレコード
ord-d0921dfb842043d7a1000c1c1daa5375
出典データセット
uspto-grants-1989_07
特許番号
US04851526

反応ノート

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