Diethylamine → HCID 20031339、化合物

HRID 232305ノート

反応式

HRID 232305 の反応式
CS(O[CH2:6][CH:7]1[CH2:9][CH:8]1[C:10]#[N:11])(=O)=O.[CH2:12]([NH:14][CH2:15][CH3:16])[CH3:13]>CO>[CH2:12]([N:14]([CH2:6][CH:7]1[CH2:9][CH:8]1[C:10]#[N:11])[CH2:15][CH3:16])[CH3:13]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 20031330HCID 20031330、化合物

生成物 1

HCID 20031339HCID 20031339、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 10 mL of methanol add 1.75 g (2.10 mmol) of 2-[[(methylsulfonyl)oxy]methyl]cyclopropanecarbonitrile and 2.0 g (27 mmol) of diethylamine. Reflux the reaction and monitor by thin-layer chromatography. Upon completion remove the solvent in vacuo and add 50 mL methylene chloride and 50 mL sat. sodium carbonate. Separate the organic layer and dry over Na2SO4. Filter the drying agent and remove the solvent in vacuo to obtain the title compound.

後処理

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. customUpon completion remove the solvent in vacuo
  4. additionadd 50 mL methylene chloride and 50 mL sat. sodium carbonate
  5. customSeparate the organic layer
  6. dry with materialdry over Na2SO4
  7. filtrationFilter the drying agent
  8. customremove the solvent in vacuo

出典と根拠

ORDレコード
ord-7625e6a393a94d918be54bfae1662d0b
出典データセット
uspto-grants-1989_07
特許番号
US04851526

反応ノート

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