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N-[2-(4-Methylphenoxy)ethyl]acetamide → N-Ethyl-2-(4-methylphenoxy)ethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[2-(4-Methylphenoxy)ethyl]acetamide | HCID 538338 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | N-Ethyl-2-(4-methylphenoxy)ethanamine | HCID 20031351 | — |
反応手順
To a chilled suspension of 0.49 g (013 mol) lithium aluminium hydride in 50 mL anhydrous ether, add 5.0 g (025 mol) N-[2-(4-methylphenoxy)ethyl]acetamide at a rate which maintains the reaction temperature below 10° C. Allow to warm to room temperature and stir at ambient temp. for 24 hrs. After this time, quench the mixture with H2O and filter the salts. Concentrate the filtrate to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04851526 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-936c3c50aef24950848ed4c0bb4bc33b |
| 出典メモ | uspto-grants-1989_07 |