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2-Chloroethanol → N-Ethyl-N-(2-hydroxyethyl)-N-[2-(4-methylphenoxy)ethyl]-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloroethanol | HCID 34 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-Ethyl-2-(4-methylphenoxy)ethanamine | HCID 20031351 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-Ethyl-N-(2-hydroxyethyl)-N-[2-(4-methylphenoxy)ethyl]-amine | HCID 20031320 | — |
反応手順
Add 0.90 g (011 mol) 2-chloroethanol to a solution of 2.0 g (0.11 mol) N-ethyl-N-[2-(4-methylphenoxy)ethyl]amine and 1.7 g (012 mol) potassium carbonate in 50 mL methanol. Stir at room temperature for 24 hr. After this time, remove the solvents in vacuo and dissolve the residue in 25 mL water. Adjust the aqueous to pH=8 with 5% sodium bicarbonate solution and extract 3×50 mL methylene chloride. Dry the combined organics over sodium sulfate and evaporate the solvent to obtain the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04851526 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-f2eb8d7c4d324159a69739c911fcf09a |
| 出典メモ | uspto-grants-1989_07 |