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Tetrahydrofuran → (r)-4-Phenyl-2-oxazolidinone tetra n-butylammonium salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | (4R)-4-phenyl-1,3-oxazolidin-2-one | HCID 730425 | — |
| 触媒 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 生成物 | (r)-4-Phenyl-2-oxazolidinone tetra n-butylammonium salt | HCID 86752286 | — |
反応手順
To a stirred solution of (R)-4-phenyl-2-oxazolidinone (174 mg, 1.06 mmol) in THF (4 mL) at 0° C., add NaH (4.3 mg, 60% emulsion in oil, 0.106 mmol). Allow the temperature to rise to room temperature over 30 min., then add tetra n-butylammonium bromide (34 mg, 0.106 mmol) to the mixture and stir for another 30 min. to obtain (R)-4-phenyl-2-oxazolidinone tetra n-butylammonium salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728827 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-b9cf0611d38749c6a169a2037a147be6 |
| 出典メモ | uspto-grants-1998_03 |