Hydrochloric Acid → Bronopol

HRID 232400

反応式

HRID 232400 の反応式
CC1(C)[O:7][CH2:6][C:5]([N+:9]([O-:11])=[O:10])([Br:8])[CH2:4][O:3]1.Cl>CO>[CH2:4]([OH:3])[C:5]([Br:8])([N+:9]([O-:11])=[O:10])[CH2:6][OH:7]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 137039755-Bromo-2,2-dimethyl-5-nitro-1,3-dioxane

生成物 1

HCID 2450Bronopol収率 95%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a 50 ml round bottom flask equipped with a stir bar and reflux condensor topped with a nitrogen inlet was added 0.5 g (.004 mol) 2,2-dimethyl-5-nitro-5-bromo-1,3-dioxane, 10 ml methanol and 0.3ml concentrated HCl. The reaction was heated to 35°-40° C. for 1 hour. After cooling to room temperature, the volatiles were removed to give crystalline bronopol (95% yield) which on recrystallization from acetone had a melting point of 120° C.

後処理

  1. customTo a 50 ml round bottom flask equipped with a stir bar
  2. temperaturereflux condensor
  3. customtopped with a nitrogen inlet
  4. temperatureThe reaction was heated to 35°-40° C. for 1 hour
  5. customthe volatiles were removed

出典と根拠

ORDレコード
ord-2dc690ba18b344c98fad6e1070d3f913
出典データセット
uspto-grants-1989_07
特許番号
US04851588

関連ノート

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