Isophthalaldehyde → 3-(2-(7-Chloroquinolin-2-yl)vinyl)benzaldehyde

HRID 232420ノート

反応式

HRID 232420 の反応式
[CH:1](=[O:10])[C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([CH:5]=O)[CH:3]=1.[Cl:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH3:22])=[N:19]2)=[CH:14][CH:13]=1>C(OC(=O)C)(=O)C.CCOCC>[Cl:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH:22]=[CH:5][C:4]3[CH:3]=[C:2]([CH:9]=[CH:8][CH:7]=3)[CH:1]=[O:10])=[N:19]2)=[CH:14][CH:13]=1

参加物

5

反応物 2

HCID 34777IsophthalaldehydeHCID 1383957-Chloro-2-methylquinoline

生成物 1

HCID 533948533-(2-(7-Chloroquinolin-2-yl)vinyl)benzaldehyde

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 7918Acetic Anhydride溶媒

実験手順

A solution of isophthalaldehyde (4.0 g) and 7-chloroquinaldine (5.39 g) in acetic anhydride was heated at 125° C. in an oil bath for 48 hours. The reaction was cooled to room temperature, diluted with ether (30 mL) and the resulting suspension was stirred vigorously. The solid title compound was collected by filtration and was used as such in the next step.

後処理

  1. filtrationThe solid title compound was collected by filtration

出典と根拠

ORDレコード
ord-a09e302a80a04351bff75b030e91b80f
出典データセット
uspto-grants-1989_07
特許番号
US04851409

反応ノート

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