Potassium Cyanide → 2-(3,5-Dichlorophenyl)acetonitrile
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH2:5]Cl.[C-:11]#[N:12].[K+]>ClCCl.S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:5][C:11]#[N:12])[CH:7]=[C:8]([Cl:10])[CH:9]=1参加物
6
実験手順
To a vigorously stirred solution of 3,5-dichlorobenzylchloride (28 g) in dichloromethane (150 ml) was added a mixture of KCN (27.5 g) and tetrabutylammonium hydrogen sulphate (2.38 g) in water (110 ml). After stirring at room temperature for 22 hours, the mixture was diluted with dichloromethane, the organic phase washed with water and concentrated in vacuo to leave an oil. Filtration through silica with toluene followed by concentration then trituration with hexane gave the desired product as a colourless solid. 15.8 g, mp. 31°-32° C.
後処理
- washthe organic phase washed with water
- concentrationconcentrated in vacuo
- customto leave an oil
- filtrationFiltration through silica with toluene
- concentrationfollowed by concentration
出典と根拠
- ORDレコード
- ord-b467563f072e4b279b42eeb189668640
- 出典データセット
- uspto-grants-1997_01
- 特許番号
- US05591746
反応ノート
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