2-Bromo-1-chloro-4-(trifluoromethyl)benzene → (7Br,11as)-n-[2-chloro-5-(trifluoromethyl)phenyl]-1,2,7b,8,9,10,11,11a-octahydro-4h-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indol-6-amine

HRID 23266

反応式

HRID 23266 の反応式
Br[C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[NH2:13][C:14]1[CH:15]=[C:16]2[C:20]3=[C:21]([CH2:23][S:24][CH2:25][CH2:26][N:19]3[C@H:18]3[CH2:27][CH2:28][N:29](C(OC(C)(C)C)=O)[CH2:30][C@@H:17]23)[CH:22]=1>>[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]([F:12])([F:11])[F:10])=[CH:3][C:2]=1[NH:13][C:14]1[CH:15]=[C:16]2[C:20]3=[C:21]([CH2:23][S:24][CH2:25][CH2:26][N:19]3[C@H:18]3[CH2:27][CH2:28][NH:29][CH2:30][C@@H:17]23)[CH:22]=1

参加物

3

反応物 2

HCID 679882-Bromo-1-chloro-4-(trifluoromethyl)benzeneHCID 86586437tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indole-9(8H) carboxylate

生成物 1

HCID 60071861(7Br,11as)-n-[2-chloro-5-(trifluoromethyl)phenyl]-1,2,7b,8,9,10,11,11a-octahydro-4h-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indol-6-amine

実験手順

Using 3-bromo-4-chlorobenzotrifluoride and following the procedures described in EXAMPLE 33, Parts C and D, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indole-9(8H)-carboxylate from EXAMPLE 33, Part B was converted into the title compound of EXAMPLE 38 as a powder. 1H NMR (CDCl3, 300 MHz) 1.82-1.87 (m, 4H), 2.58-2.65 (m, 1H), 2.82-3.28 (m, 6H), 3.46-3.51 (m, 1H), 3.62-3.65 (m, 1H), 3.76 (s, 2H), 6.04 (s, 1H), 6.73 s, 1H), 6.83 (s, 1H), 6.91 (d, 1H, J=8 Hz), 7.14 (s, 1H), 7.37 (d, 1H, J=8 Hz). LRMS ES)+: 440 (M+H)+.

出典と根拠

ORDレコード
ord-9eafa7ba292e4ca896f7d716be339e82
出典データセット
uspto-grants-2005_02
特許番号
US06849619B2

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