Hydrochloric Acid → HCID 23359009、化合物

HRID 232662ノート

反応式

HRID 232662 の反応式
[F:1][C:2]1[C:11]([CH3:12])=[C:10]([F:13])[C:9]([F:14])=[C:8]([N+:15]([O-:17])=[O:16])[C:3]=1[NH:4]C(=O)C.Cl.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[F:1][C:2]1[C:11]([CH3:12])=[C:10]([F:13])[C:9]([F:14])=[C:8]([N+:15]([O-:17])=[O:16])[C:3]=1[NH2:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 23359014HCID 23359014、化合物

生成物 1

HCID 23359009HCID 23359009、化合物収率 118.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 2,4,5-trifluoro-3-methyl-6-nitro-N-acetyl-aniline (2.08 g) are added ethanol (30 ml) and 10% hydrochloric acid (30 ml) and the mixture is refluxed for 3 hours. After cooling, the reaction mixture is poured into ice-water, neutralized with potassium carbonate, extracted with dichloromethane and the extract is dried. The solvent is distilled off under reduced pressure to give 2,4,5-trifluoro-3-methyl-6-nitroaniline (2.05 g), as brown crystals.

後処理

  1. temperaturethe mixture is refluxed for 3 hours
  2. temperatureAfter cooling
  3. extractionextracted with dichloromethane
  4. customthe extract is dried
  5. distillationThe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-33b8a79a66b94f97a070e79e0bf85ca2
出典データセット
uspto-grants-1997_01
特許番号
US05591744

反応ノート

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