Aluminum(III) Chloride → 6-Carboxy-8-methylcarbostyril

HRID 232703

反応式

HRID 232703 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[C:5]([NH:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([OH:22])=[O:21])=[CH:18][C:17]=1[CH3:25])(=[O:14])[CH:6]=[CH:7]C1C=CC=CC=1>ClC1C=CC=CC=1>[C:20]([C:19]1[CH:23]=[C:24]2[C:16](=[C:17]([CH3:25])[CH:18]=1)[NH:15][C:5](=[O:14])[CH:6]=[CH:7]2)([OH:22])=[O:21]

参加物

4

反応物 2

HCID 6451240Aluminum(III) ChlorideHCID 538459644-Cinnamoylamino-3-methylbenzoic acid

生成物 1

HCID 233590966-Carboxy-8-methylcarbostyril収率 49.8%

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

反応条件

温度
90 °C

実験手順

7.1 g of aluminum chloride was added to a solution of 2.5 g of 4-cinnamoylamino-3-methylbenzoic acid in 12.5 ml of chlorobenzene. The mixture was stirred at 90° C. for 1 hour to give rise to a reaction. The reaction mixture was poured into ice water. The resulting precipitate was collected by filtration and dispersed in 70 ml of ethanol and 70 ml of water. The dispersion was made alkaline with a 30% aqueous sodium hydroxide solution and then treated with active carbon. The resulting material was made acidic with concentrated hydrochloric acid. The resulting precipitate was collected by filtration and then washed with hot ethanol to obtain 0.9 g of 6-carboxy-8-methylcarbostyril as a light brown powder.

後処理

  1. customto give rise
  2. customto a reaction
  3. filtrationThe resulting precipitate was collected by filtration
  4. additiondispersed in 70 ml of ethanol
  5. additiontreated with active carbon
  6. filtrationThe resulting precipitate was collected by filtration
  7. washwashed with hot ethanol

出典と根拠

ORDレコード
ord-c727b096a0914ce581ea03480a96ad4d
出典データセット
uspto-grants-1997_01
特許番号
US05591751

関連ノート

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