4-Bromo-5-chlorothiophene-2-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-4-bromo-5-chloro-thiophene-2-sulfonamide

反応式

[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Br:9][C:10]1[CH:11]=[C:12]([S:16](Cl)(=[O:18])=[O:17])[S:13][C:14]=1[Cl:15]>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:16]([C:12]1[S:13][C:14]([Cl:15])=[C:10]([Br:9])[CH:11]=1)(=[O:18])=[O:17]

参加物

反応物 2

HCID 27972204-Bromo-5-chlorothiophene-2-sulfonyl chloride

HCID 104875194-Bromo-3-methylisoxazol-5-amine

生成物 1

HCID 15342063N-(4-Bromo-3-methyl-5-isoxazolyl)-4-bromo-5-chloro-thiophene-2-sulfonamide収率 25%

実験手順

N-(4-Bromo-3-methyl-5-isoxazolyl)-4-bromo-5-chloro-thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 4-bromo-5-chlorothiophene-2-sulphonyl chloride in 25% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 143°-145° C.

後処理

customPurification
customwas achieved by recrystallization from ethyl acetate/hexanes
customto give a crystalline solid, m.p. 143°-145° C.

出典と根拠

ORDレコード: ord-b36f574adcf54b81930a0f8630ee57dc
出典データセット: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05591761

反応ノート

読み込み中…

参加物