化工社化工社 化学情報印刷レポート · 研究参考用
Pregnenolone → Isopregnanolone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pregnenolone | HCID 8955 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Isopregnanolone | HCID 92787 | 96.2% |
反応手順
A mixture of 3β-hydroxy-5-pregnen-20-one (980 mg, 316.5 g/m, 3.1 mmol) and 50 mg of 5% Pd/C in 50 mL of absolute ethyl alcohol was stirred under 1 atmosphere of hydrogen gas for 5 hours at room temperature. The reaction was filtered through a celite pad and the filtrate evaporated under reduced pressure to give 950 mg of 3β-hydroxy-5α-pregnan-20-one (96% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05591733 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-46dff4cc51f745f9a769e0a0f3cd1dbe |
| 出典メモ | uspto-grants-1997_01 |