7-Chloro-6-fluoro-2-formylquinoline → (7-Chloro-6-fluoroquinolin-2-yl)methanol

HRID 232866

反応式

HRID 232866 の反応式
B.[Na].[Cl:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][C:10]([CH:14]=[O:15])=[N:11]2)=[CH:6][C:5]=1[F:16]>CO>[Cl:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][C:10]([CH2:14][OH:15])=[N:11]2)=[CH:6][C:5]=1[F:16]

参加物

4

反応物 2

HCID 233591737-Chloro-6-fluoro-2-formylquinolineHCID 178418435HCID 178418435、化合物

生成物 1

HCID 23359111(7-Chloro-6-fluoroquinolin-2-yl)methanol収率 69.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3 g of sodium boron hydride was added to 11.19 g of 7-chloro-6-fluoro-2-formylquinoline obtained in Reference example 2 suspended in 250 ml of methanol and the mixture was stirred at room temperature for 1 hour. After the solvent was removed, the residue was extracted with ice water-methylene chloride and the organic layer was washed with water and dried over anhydrous sodium sulfate. After the solvent was removed, the residue was applied to silica gel column chromatography to obtain 7.84 g of the title compound.

後処理

  1. customobtained in Reference example 2
  2. customAfter the solvent was removed
  3. extractionthe residue was extracted with ice water-methylene chloride
  4. washthe organic layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. customAfter the solvent was removed

出典と根拠

ORDレコード
ord-20468624d1b34544a12da48e15e04df3
出典データセット
uspto-grants-1997_01
特許番号
US05591752

関連ノート

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