Hydrochloric Acid → Methyl 5-cyano-2-methylbenzoate

0.5 g of cuprous cyanide was added to 1 g of methyl 4-bromo-o-toluate obtained in Reference example 18 dissolved in 0.7 ml of dimethylformamide and the mixture was refluxed under heating for 6 hours. Then, to the reaction mixture were added 2.6 ml of water, 0.5 ml of conc. hydrochloric acid and 1.75 g of ferric chloride and the mixture was stirred at 60° to 70° C. for 30 minutes. After the reaction mixture was extracted with ethyl acetate, the organic layer was washed with a saturated saline solution and dried over anhydrous sodium sulfate. The solvent was removed from the solution to obtain 0.76 g of the title compound.

1. customobtained in Reference example 18
2. temperaturethe mixture was refluxed
3. temperatureunder heating for 6 hours
4. extractionAfter the reaction mixture was extracted with ethyl acetate
5. washthe organic layer was washed with a saturated saline solution
6. dry with materialdried over anhydrous sodium sulfate
7. customThe solvent was removed from the solution

ORDレコード

ord-0a46ed268c724a50bce1ceb17529e8a6

出典データセット

uspto-grants-1997_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05591752