Ethyl 4-amino-4-(3-methoxyphenyl)butanoate → 5-(3-Methoxyphenyl)-2-pyrrolidinone

HRID 233013ノート

反応式

HRID 233013 の反応式
[NH2:1][CH:2]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=1)[CH2:3][CH2:4][C:5](OCC)=[O:6]>C1(C)C=CC=CC=1>[CH3:17][O:16][C:12]1[CH:11]=[C:10]([CH:2]2[NH:1][C:5](=[O:6])[CH2:4][CH2:3]2)[CH:15]=[CH:14][CH:13]=1

参加物

3

反応物 1

HCID 23361303Ethyl 4-amino-4-(3-methoxyphenyl)butanoate

生成物 1

HCID 152932255-(3-Methoxyphenyl)-2-pyrrolidinone収率 90%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Ethyl 4-amino-4-(3-methoxyphenyl)butanoate (9.39 g) was dissolved in toluene (50 ml) and the solution heated under reflux for 0.5 hr to 1.0 hr. The mixture was cooled to ambient temperature, the precipitate was collected, and the filtrate was concentrated. The residue was recrystallized from ether to give 6.80 g (90%) of product, mp 84°-85° C.

後処理

  1. temperaturethe solution heated
  2. temperatureunder reflux for 0.5 hr to 1.0 hr
  3. customthe precipitate was collected
  4. concentrationthe filtrate was concentrated
  5. customThe residue was recrystallized from ether

出典と根拠

ORDレコード
ord-925a4b518fad48d7b89d204dd678c834
出典データセット
uspto-grants-1997_01
特許番号
US05591856

反応ノート

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