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Hydrochloric Acid → L-homoalanin-4-yl(methyl)phosphinic acid hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | (4S)-3-benzyloxycarbonyl-4-{2-[ethoxy(methyl)phosphinyl]ethyl}-1,3-oxazolidin-5-one | HCID 14596286 | — |
| 生成物 | L-homoalanin-4-yl(methyl)phosphinic acid hydrochloride | HCID 12701464 | 82.1% |
反応手順
0.50 g (1.4 mmol) of (4S)-3-benzyloxycarbonyl-4-{2-[ethoxy(methyl)phosphinyl]ethyl}-1,3-oxazolidin-5-one (from Example 12) are, as described in DE-A-3,817,956, hydrolyzed by heating in 6N hydrochloric acid. 0.25 g (82.1% of theory) of L-homoalanin-4-yl(methyl)phosphinic acid hydrochloride are obtained as a white solid having a melting point of Mp 202° C. (decomposition).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05591861 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-b0624cfe68d740beaf2791a7ab5ec070 |
| 出典メモ | uspto-grants-1997_01 |