4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]cinnamonitrile → HCID 10969638、化合物

関与物質

反応手順

A mixture of 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]cinnamonitrile (4.0 g), palladium-carbon (5%, 0.5 g ) and ethyl acetate (50 ml) was subjected to catalytic hydrogenation at room temperature under 1 atmospheric pressure. The catalyst was filtered off, then the filtrate was concentrated under reduced pressure to leave 3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propionitrile (3.7 g, 93%). The product was recrystallized from ethyl acetate--hexane to give colorless needles, m.p.109°-110° C.

情報源と証拠