N,N-Dimethyl-1,3-propanediamine → tert-Butyl 4-(2-(3-(Dimethylamino)propylamino)quinazolin-4-ylamino)piperidine-1-carboxylate

反応式

[CH3:26][N:27]([CH3:28])[CH2:29][CH2:30][CH2:31][NH2:32].[Cl:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]([NH:12][CH:13]2[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]2)[n:11]1.[O:33]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1>>[c:2]1([NH:32][CH2:31][CH2:30][CH2:29][N:27]([CH3:26])[CH3:28])[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]([NH:12][CH:13]2[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]2)[n:11]1

参加物

反応物 3

HCID 7993N,N-Dimethyl-1,3-propanediamine

HCID 312751,4-Dioxane

HCID 58006142tert-Butyl 4-((2-chloroquinazolin-4-yl)amino)piperidine-1-carboxylate

生成物 1

HCID 58006221tert-Butyl 4-(2-(3-(Dimethylamino)propylamino)quinazolin-4-ylamino)piperidine-1-carboxylate

出典と根拠

ORDレコード: ord-6ed68474178c4bebaca37a01bd55a8f7
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…