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HRID 233377作成日：2026年10月26日

(S)-Benzyl 2-amino-3-(4-hydroxyphenyl)propanoate → N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester

https://huagongshe.com/reaction/233377

反応式

関与物質

役割名称HCID仕込み量
反応物(S)-Benzyl 2-amino-3-(4-hydroxyphenyl)propanoateHCID 104541—
反応物2-Acetylthiomethyl-3-(4-hydroxyphenyl)butanoic acidHCID 18980788—
生成物N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl esterHCID 1007539878%

反応手順

Using the procedure described in Example 60, but starting with 2-acetylthiomethyl-3-(4-hydroxyphenyl)butanoic acid and tyrosine benzyl ester, N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester is obtained in a 78% yield in the form of a white solid, having the following characteristics: Rf =0.16 [hexane/ethyl acetate (65:35 by volume)].

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05591891
出典データセットuspto-grants-1997_01
ORD IDord-88813f320fae41578e2924c624159cdb
出典メモuspto-grants-1997_01