Acetic Anhydride → HCID 19961181、化合物

HRID 233415ノート

反応式

HRID 233415 の反応式
[NH2:1][CH2:2][C:3]1[C:12]2[C:7](=[C:8]([OH:14])[C:9]([OH:13])=[CH:10][CH:11]=2)[CH2:6][CH:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22].C(N(CC)CC)C>C(Cl)Cl>[C:21]([NH:1][CH2:2][C:3]1[C:12]2[C:7](=[C:8]([OH:14])[C:9]([OH:13])=[CH:10][CH:11]=2)[CH2:6][CH:5]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:4]=1)(=[O:23])[CH3:22]

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 199610761-Aminomethyl-3-phenyl-5,6-dihydroxy-3,4-dihydronaphthalene

生成物 1

HCID 19961181HCID 19961181、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Approximately 1 mmol of 1-aminomethyl-3-phenyl-5,6-dihydroxy-3,4-dihydronaphthalene, from Example 2, was reacted with 1.2 mmol of acetic anhydride in the presence of 1.2 mmol of triethylamine in an excess of methylene chloride. The mixture was washed with 0.1N HCl, and dried. The product was precipitated by addition of ether, collected, and dried. mp 238° C. MS M/Z: 310. Anal. calc. for C19H19NO3.HBr C: 65.03; H, 5.72; N, 3.61; found: C, 73.46; H, 6.13; N, 4.49.

後処理

  1. washThe mixture was washed with 0.1N HCl
  2. customdried
  3. customThe product was precipitated by addition of ether
  4. customcollected
  5. customdried

出典と根拠

ORDレコード
ord-3f680a6789be409584c74bcc12815f78
出典データセット
uspto-grants-1997_01
特許番号
US05591884

反応ノート

読み込み中…