3-Butyn-2-amine, 2-methyl- → HCID 131718820、化合物
反応式
C(O[C:4]([C:6]1[C:11](=[O:12])[NH:10][C:9]2[CH:13]=[CH:14][S:15][C:8]=2[C:7]=1[OH:16])=[O:5])C.[CH3:17][C:18]([NH2:22])([C:20]#[CH:21])[CH3:19]>CCO>[CH3:17][C:18]([NH:22][C:4]([C:6]1[C:11](=[O:12])[NH:10][C:9]2[CH:13]=[CH:14][S:15][C:8]=2[C:7]=1[OH:16])=[O:5])([CH3:19])[C:20]#[CH:21]参加物
4
実験手順
3.1 g (13 mmol) of 6-ethoxycarbonyl-7-hydroxy-thieno[3,2-b]pyridin-5(4H)-one and 1.3 g (1.2 eq.) of 1,1-dimethylpropargylamine in 80 ml of EtOH were stirred for 8 hours at 150° C. in an autoclave. The solvent was removed under reduced pressure and the solid residue was stirred with diethyl ether. The solid was filtered off and purified chromatographically (silica gel, methylene chloride/methanol=8/1).
後処理
- customThe solvent was removed under reduced pressure
- filtrationThe solid was filtered off
- custompurified chromatographically (silica gel, methylene chloride/methanol=8/1)
出典と根拠
- ORDレコード
- ord-c46d7196f4b44e8592e1f1cac8aa4bc7
- 出典データセット
- uspto-grants-1997_01
- 特許番号
- US05593943
反応ノート
読み込み中…