HCID 54560818、化合物 → (biphenyl-2-ylmethyl)phosphonic acid
反応式
C[O:2][P:3]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:6])[O:4]C>Cl>[C:9]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[CH2:7][P:3](=[O:2])([OH:6])[OH:4]参加物
3
実験手順
A solution of ([1,1'-Biphenyl]-2-ylmethyl)phosphonic acid dimethyl ester (Compound 6, 515 mg, 1.87 mM) in concentrated hydrochloric acid (5 mL) is heated at reflux temperature for six hours. The reaction is then allowed to stand at room temperature until a white precipitate is formed. The aqueous HC1 is removed under reduced pressure. The white solid is recrystallized from water to yield 300 mg of title compound as white crystals, mp 168.5°-169° C.
後処理
- temperatureat reflux temperature for six hours
- customto stand at room temperature until a white precipitate
- customis formed
- customThe aqueous HC1 is removed under reduced pressure
- customThe white solid is recrystallized from water
出典と根拠
- ORDレコード
- ord-64b33e3d8f594b7e872a68c62134ed10
- 出典データセット
- uspto-grants-1997_01
- 特許番号
- US05593980
反応ノート
読み込み中…