Cyclohexylthiourea → 7-[2-(Cyclohexylamino)-1,3-thiazol-5-yl]quinazolin-4(3h)-one

HRID 23357

反応式

Br[CH:2]([C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:15])[NH:10][CH:11]=[N:12]2)=[CH:7][CH:6]=1)[CH:3]=O.[CH:16]1([NH:22][C:23]([NH2:25])=[S:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>CN(C)C=O>[CH:16]1([NH:22][C:23]2[S:24][C:2]([C:5]3[CH:14]=[C:13]4[C:8]([C:9](=[O:15])[NH:10][CH:11]=[N:12]4)=[CH:7][CH:6]=3)=[CH:3][N:25]=2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

参加物

実験手順

A solution of bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde and N-cyclohexylthiourea in dimethylformamide is heated at 70° C. until completion of the reaction (5-12 hours). The mixture is quenched with 10% dimethylamine in ethanol and the solvent is removed under reduced pressured. The crude is purified by chromatography on silica gel to isolate the desired compound.

後処理

customThe mixture is quenched with 10% dimethylamine in ethanol
customthe solvent is removed
customThe crude is purified by chromatography on silica gel

出典と根拠

ORDレコード: ord-25238562fd52496693cf85f9c426924f
出典データセット: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06852720B2

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート