Methyl 3-phenyl-DL-alaninate hydrochloride → N-[(2-thiazolylamino)thioxomethyl]-DL-phenylalanine methyl ester

HRID 233697

反応式

HRID 233697 の反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7](N1C=CN=C1)=[S:8].Cl.[CH3:15][O:16][C:17](=[O:27])[CH:18]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH2:19]>CN(C)C=O>[CH3:15][O:16][C:17](=[O:27])[CH:18]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH:19][C:7]([NH:6][C:2]1[S:1][CH:5]=[CH:4][N:3]=1)=[S:8]

参加物

4

反応物 2

HCID 3084017Methyl 3-phenyl-DL-alaninate hydrochlorideHCID 10750950N-(thiazol-2-yl)-1H-imidazole-1-carbothioamide

生成物 1

HCID 19704073N-[(2-thiazolylamino)thioxomethyl]-DL-phenylalanine methyl ester収率 51%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 1-[(2-thiazolyl)thiocarbamoyl]imidazole (4.21 g, 20.0 mmol) and DL-phenylalanine methyl ester hydrochloride (4.31 g, 20.0 mmol) in N,N-dimethylformamide (150 mL) was heated at 90° C. for 3 h. The reaction was cooled to room temperature, solvent removed under reduced pressure, recrystalllized from ether-hexanes to provide 3.26 g (51%) of the titled product:

後処理

  1. customsolvent removed under reduced pressure

出典と根拠

ORDレコード
ord-6149e2af7e81423a9f39cc145aa9237d
出典データセット
uspto-grants-1997_01
特許番号
US05593993

関連ノート

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