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Methyl 3-phenyl-DL-alaninate hydrochloride → N-[(2-benzothiazolylamino)thioxomethyl]-DL-phenylalanine methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 3-phenyl-DL-alaninate hydrochloride | HCID 3084017 | — |
| 反応物 | N-(benzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide | HCID 19703709 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-[(2-benzothiazolylamino)thioxomethyl]-DL-phenylalanine methyl ester | HCID 19703398 | 70.5% |
反応手順
A solution of 1-[(2-benzothiazolyl)thiocarbamoyl]imidazole (1.30 g, 5.0 mmol) and DL-phenylalanine methyl ester hydrochloride (1.08 g, 5.0 mmol) in N,N-dimethylformamide (50 mL) was heated at 90° C. for 3 h. The reaction was cooled to room temperature, solvent removed under reduced pressure, recrystalllized from ethyl ether-hexanes to provide 1.31 g (70%) of the titled product:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05593993 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-d26e212ec36043ca9a12ae547561e4c5 |
| 出典メモ | uspto-grants-1997_01 |