2-Amino-4,5,6,7-tetrahydrobenzothiazole → HCID 19703901、化合物

HRID 233704

反応式

HRID 233704 の反応式
[C:1]1([CH2:7][CH2:8][N:9]=[C:10]=[S:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.[NH2:12][C:13]1[S:14][C:15]2[CH2:21][CH2:20][CH2:19][CH2:18][C:16]=2[N:17]=1>CN(C)C=O>[C:1]1([CH2:7][CH2:8][NH:9][C:10]([NH:12][C:13]2[S:14][C:15]3[CH2:21][CH2:20][CH2:19][CH2:18][C:16]=3[N:17]=2)=[S:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1

参加物

4

反応物 2

HCID 180462-Amino-4,5,6,7-tetrahydrobenzothiazoleHCID 27358811-(2-Isothiocyanatoethyl)cyclohex-1-ene

生成物 1

HCID 19703901HCID 19703901、化合物収率 13.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 2-(1-cyclohexenyl)ethyl isothiocyanate (1.67 g, 10 mmol) and 2-amino-4,5,6,7-tetrahydrobenzothiazole (1.54 g, 10 mmol) in N,N-dimethylformamide (100 mL) was heated at 100° C. for 120 h. The reaction was cooled to room temperature, the solvent removed under reduced pressure, the residue taken up in ethyl acetate and washed with 1N HCl. The organic layer was concentrated and the residue recrystallized from ethyl acetate-hexanes to provide 426 mg (13%) of the titled product:

後処理

  1. customthe solvent removed under reduced pressure
  2. washwashed with 1N HCl
  3. concentrationThe organic layer was concentrated
  4. customthe residue recrystallized from ethyl acetate-hexanes

出典と根拠

ORDレコード
ord-d5c227c25b4b45b1b6cd865fee535c41
出典データセット
uspto-grants-1997_01
特許番号
US05593993

関連ノート

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