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Methyl iodide → Benzilic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Bis(4-fluorophenyl)(hydroxy)acetic acid | HCID 12068839 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Benzilic acid | HCID 6463 | — |
反応手順
25.0 g (0.095 mol) of 4,4′-difluorobenzilic acid is added to freshly prepared sodium ethoxide solution containing 2.17 g (0.095 mol) of sodium and 200 ml of ethanol at 20° C. and stirred for 3 hours. The solution is evaporated to dryness, the residue is dissolved in DMF, 22.57 g (0.16 mol) of methyl iodide is added dropwise at 20° C., and the mixture is stirred for 24 hours. It is worked up and purified analogously to compound 12b. Yield: 21.06 g (80% of theory).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06852728B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-aef3a9165c004a55b2384744041b864a |
| 出典メモ | uspto-grants-2005_02 |