(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride → 7-methoxy-3-methylsulfanyl-1H-indole

HRID 23380ノート

反応式

HRID 23380 の反応式
[Cl-].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[C:9]2[S+:13](C)[CH3:14]>CS(C)=O>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[C:9]2[S:13][CH3:14]

参加物

3

反応物 1

HCID 22573983(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride

生成物 1

HCID 225741157-methoxy-3-methylsulfanyl-1H-indole収率 87.5%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride (0.742 g) prepared in the manner described in Step 1 above was dissolved in DMSO (3 ml) and placed under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask. The flask was placed on a steam bath and heated until the bubbling stopped. When no more starting material was present, the reaction mixture was cooled and partitioned between ether and water. The organic layer was dried and filtered and then evaporated to dryness to afford 7-methoxy-3-methylsulfanyl-1H-indole (0.514 g, 87.5%).

後処理

  1. customplaced under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask
  2. customThe flask was placed on a steam bath
  3. temperatureheated until the bubbling
  4. temperaturethe reaction mixture was cooled
  5. custompartitioned between ether and water
  6. customThe organic layer was dried
  7. filtrationfiltered
  8. customevaporated to dryness

出典と根拠

ORDレコード
ord-0313e01f608f4c7bb8da78f078c1e2b2
出典データセット
uspto-grants-2005_02
特許番号
US06852726B2

反応ノート

読み込み中…