Hydrochloric Acid → N-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide hydrochloride

HRID 233885

反応式

HRID 233885 の反応式
[F:1][C:2]1[CH:29]=[CH:28][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]4[C:21](=[O:22])[C:20]5=[CH:23][CH:24]=[CH:25][CH:26]=[C:19]5[C:18]4=[O:27])[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1.[ClH:30]>ClCCl.C(O)C.CCOCC>[ClH:30].[F:1][C:2]1[CH:29]=[CH:28][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]4[C:18](=[O:27])[C:19]5=[CH:26][CH:25]=[CH:24][CH:23]=[C:20]5[C:21]4=[O:22])[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 98653575-HT6/7 antagonist 1

生成物 1

HCID 18467219N-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide hydrochloride

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 21584144Dichloromethane ethanol溶媒

実験手順

To a solution of 8.0 g of N-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide in dichloromethane/ethanol (150 ml) was added 1M - HCl in ether. The salt crystallized out rapidly. It was filtered off, washed with ethanol and dried to afford 8.15 g withm.p.=257°-259° C., dec. Recrystallization provided 7.20 g of pure white salt, with m.p. unchanged.

後処理

  1. customThe salt crystallized out rapidly
  2. filtrationIt was filtered off
  3. washwashed with ethanol
  4. customdried
  5. customto afford 8.15 g
  6. customRecrystallization

出典と根拠

ORDレコード
ord-2c981c39c6fc4fd99c0e3a819728978a
出典データセット
uspto-grants-1997_01
特許番号
US05593995

関連ノート

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