Dimethylamine → 2-nitrobenzyl-N,N-dimethylsulfonamide

HRID 23394

反応式

HRID 23394 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][S:11](Cl)(=[O:13])=[O:12])([O-:3])=[O:2].[CH3:15][NH:16][CH3:17]>O1CCOCC1>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][S:11]([N:16]([CH3:17])[CH3:15])(=[O:13])=[O:12])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 674DimethylamineHCID 4305447(2-nitrophenyl)methanesulfonyl Chloride

生成物 1

HCID 131787262-nitrobenzyl-N,N-dimethylsulfonamide収率 85%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

2-Nitro-α-toluenesulfonyl chloride (0.943 g, 4.0 mmole) was dissolved in dry dioxane (7 ml) and treated with a solution of dimethylamine (4 ml 2M solution in THF, 8.0 mmole), and stirred at room temperature for a total of 6 h. The reaction mixture was transferred to a separatory funnel and partitioned between ethyl acetate and water. The organic solution was washed with brine, dried over magnesium sulfate, filtered and evaporated to dryness to afford the pure 2-nitrobenzyl-N,N-dimethylsulfonamide, 0.829 g (85% yield).

後処理

  1. customThe reaction mixture was transferred to a separatory funnel
  2. custompartitioned between ethyl acetate and water
  3. washThe organic solution was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-72587823e0244b7bbf8e4b0bdd642b13
出典データセット
uspto-grants-2005_02
特許番号
US06852726B2

関連ノート

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