Hydroxyacetic acid--2-hydroxypropanoic acid (1/1) → Ethyl ester of lactic acid glycolic acid
反応式
[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[OH:3].[C:7]([OH:11])(=[O:10])[CH2:8][OH:9].[N+](=CC)=[N-]>ClCCl>[CH3:7][CH2:8][O:5][C:1]([CH:2]([OH:3])[CH3:4])=[O:6].[C:7]([OH:11])(=[O:10])[CH2:8][OH:9]参加物
4
実験手順
130 g of lactic acid/glycolic acid copolymer having a weight-average molecular weight of about 5,000, (lactic acid/glycolic acid=50/50 (mol %)) was dissolved in 1,900 ml of dichloromethane; this solution was stirred and cooled. While the solution was ice cooled, the above-described diazoethane solution was added dropwise, followed by stirring at room temperature for 2 hours. After the solution was kept standing overnight, the solvent was distilled off under reduced pressure; the residue was vacuum dried at room temperature to yield 131 g of the ethyl ester of lactic acid/glycolic acid.
後処理
- temperaturecooled
- temperaturecooled
- stirringby stirring at room temperature for 2 hours
- distillationthe solvent was distilled off under reduced pressure
- customdried at room temperature
出典と根拠
- ORDレコード
- ord-964e102c196d46ae806bc5893ec44bb2
- 出典データセット
- uspto-grants-1997_01
- 特許番号
- US05594091
反応ノート
読み込み中…