Bromine → 6-Bromo-1H-indole-3-carboxylic acid
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([OH:12])=[O:11])=[CH:2]1.[Br:13]Br>C(O)(=O)C>[Br:13][C:7]1[CH:8]=[C:9]2[C:4]([C:3]([C:10]([OH:12])=[O:11])=[CH:2][NH:1]2)=[CH:5][CH:6]=1参加物
4
反応条件
- 温度
- 15 °C
実験手順
To a solution of indole-3-carboxylic acid (4.81 g, 30 mmole) in acetic acid (50 ml), bromine was added dropwise with stirring at 15° C. After stirring overnight at room temperature the reaction mixture was set aside without stirring for 24 hours during which time pure product crystallized from solution. The precipitate was collected and dried to afford 1.29 g pure 6-bromoindole-3-carboxylic acid. The mother liquor was poured into water (250 ml) and another crop of product was obtained (3.84 g) as a 1:1 mixture of the 6-bromo- and the 5-bromoindole-3-carboxylic acid.
後処理
- stirringAfter stirring overnight at room temperature the reaction mixture
- stirringwithout stirring for 24 hours during which time pure product
- customcrystallized from solution
- customThe precipitate was collected
- customdried
出典と根拠
- ORDレコード
- ord-041984c22f354fbca34f7500f39174d9
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06852726B2
反応ノート
読み込み中…