5-((4-Chlorobenzamido)methyl)thiophene-2-sulfonyl chloride → HCID 15342061、化合物
反応式
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Cl:9][C:10]1[CH:28]=[CH:27][C:13]([C:14]([NH:16][CH2:17][C:18]2[S:22][C:21]([S:23](Cl)(=[O:25])=[O:24])=[CH:20][CH:19]=2)=[O:15])=[CH:12][CH:11]=1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:23]([C:21]1[S:22][C:18]([CH2:17][NH:16][C:14](=[O:15])[C:13]2[CH:27]=[CH:28][C:10]([Cl:9])=[CH:11][CH:12]=2)=[CH:19][CH:20]=1)(=[O:25])=[O:24]参加物
3
実験手順
N-(4-Bromo-3-methyl-5-isoxazolyl)-5-(4-chlorobenzamidomethyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 5-(4-chlorobenzamidomethyl)thiophene-2-sulphonyl chloride in 27% yield. The crude product was passed through a silica gel column using hexanes/ethyl acetate as eluent. Purification was effected by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 210° C. (dec).
後処理
- customPurification
- customwas effected by recrystallization from ethyl acetate/hexanes
- custom