4-Bromo-5-chlorothiophene-2-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-4-bromo-5-chloro-thiophene-2-sulfonamide

HRID 234300

反応式

HRID 234300 の反応式
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Br:9][C:10]1[CH:11]=[C:12]([S:16](Cl)(=[O:18])=[O:17])[S:13][C:14]=1[Cl:15]>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:16]([C:12]1[S:13][C:14]([Cl:15])=[C:10]([Br:9])[CH:11]=1)(=[O:18])=[O:17]

参加物

3

反応物 2

HCID 27972204-Bromo-5-chlorothiophene-2-sulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

生成物 1

HCID 15342063N-(4-Bromo-3-methyl-5-isoxazolyl)-4-bromo-5-chloro-thiophene-2-sulfonamide収率 25%

実験手順

N-(4-Bromo-3-methyl-5-isoxazolyl)-4-bromo-5-chloro-thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 4-bromo-5-chlorothiophene-2-sulphonyl chloride in 25% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 143°-145° C.

後処理

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give a crystalline solid, m.p. 143°-145° C.

出典と根拠

ORDレコード
ord-bc6ae6374cde47dd9073179f27762475
出典データセット
uspto-grants-1997_01
特許番号
US05594021

関連ノート

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