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2,5-Dichlorothiophene-3-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichlorothiophene-3-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-Dichlorothiophene-3-sulfonyl chloride | HCID 2736094 | — |
| 反応物 | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| 生成物 | N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichlorothiophene-3-sulfonamide | HCID 15342064 | 47% |
反応手順
N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichlorothiophene-3-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 2,5-dichlorothiophene-3-sulphonyl chloride in 47% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 135°-138° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05594021 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-451f5ebd67574ae98b00f67cf3b07dec |
| 出典メモ | uspto-grants-1997_01 |