5-Amino-3,4-dimethylisoxazole → N-(3,4-Dimethyl-5-isoxazolyl)benzo[b]furan-2-sulfonamide

HRID 234323

反応式

HRID 234323 の反応式
[CH3:1][C:2]1[C:6]([CH3:7])=[C:5]([NH2:8])[O:4][N:3]=1.[O:9]1[C:13]([S:14](Cl)(=[O:16])=[O:15])=[CH:12][C:11]2[CH:18]=[CH:19][CH:20]=[CH:21][C:10]1=2>>[CH3:1][C:2]1[C:6]([CH3:7])=[C:5]([NH:8][S:14]([C:13]2[O:9][C:10]3[CH:21]=[CH:20][CH:19]=[CH:18][C:11]=3[CH:12]=2)(=[O:15])=[O:16])[O:4][N:3]=1

参加物

3

反応物 2

HCID 883175-Amino-3,4-dimethylisoxazoleHCID 27951721-Benzofuran-2-sulfonyl chloride

生成物 1

HCID 22998530N-(3,4-Dimethyl-5-isoxazolyl)benzo[b]furan-2-sulfonamide

実験手順

N-(3,4-Dimethyl-5-isoxazolyl)benzo[b]furan-2-sulfonamide was prepared, in the same manner as described in Example 34B, from 3,4-dimethyl-5-amino isoxazole (78 mg, 0.70 mmol) and benzo[b]furan-2-sulfonyl chloride (0.46 g, 2.1 mmol) Flash chromatography (30% ethyl acetate/hexanes) provided 0.186 g of a light yellow solid, which was treated with 31 mg of NaOH in 10 ml of methanol at 25° C. for 30 minutes. Recrystallization from CHCl3 /hexanes yielded a light tan solid (90 mg, 44% yield), m.p. 160.5°-163° C.

出典と根拠

ORDレコード
ord-47958b60ee4f4d8c97731083eba898b7
出典データセット
uspto-grants-1997_01
特許番号
US05594021

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