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2-Formylphenylboronic acid → N-(3-methyl-5-isoxazolyl)-5-(2-formylphenyl)thiophene-2-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Formylphenylboronic acid | HCID 292189 | — |
| 反応物 | N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide | HCID 22998516 | — |
| 生成物 | N-(3-methyl-5-isoxazolyl)-5-(2-formylphenyl)thiophene-2-sulfonamide | HCID 22998472 | 28% |
反応手順
N-(3-methyl-5-isoxazolyl)-5-(2-formylphenyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 32C from 2-formylbenzeneboronic acid (281 mg, 1.87 mmol) and N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide (550 mg, 1.7 mmol). Purification by column chromatography using 15% MeOH/CHCl3 gave 63 mg (28%) of the pure sulfonamide as a brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05594021 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-7792e2d006364e329d565325598d9ef0 |
| 出典メモ | uspto-grants-1997_01 |